The two sides have almost identical records against each other with 43 wins for Southend and 44 for Town. They shared six goals in an exciting clash at Sixfields earlier this season.
Click below to look at the full head-to-head record of the two sides.
http://www.northamptontown-mad.co.uk/head_to_head/next/vs/match/index.shtml
Southend's home defeat at the hands of Cheltenham on Tuesday night means they go into the Northampton game one place and one point behind their opponents.
Town, meanwhile, have been squeezed out of the play-off places by Rotherham's win at Torquay.