The game brings together a Bees side without a point to date and a Northampton team who made it two wins from two when beating Exeter City 3-0 on Saturday.
Manager Chris Wilder was quick, however, to play down his side's early season form and felt that Town did not play well against the Grecians.
Speaking to BBC Radio Northampton he said: "We were off the pace and made bad decisions."
Opposite number Paul Tisdale had the reverse emotion, being pleased with his team's display despite his disappointment at the result.
Barnet have faced a tough start to life back in the Football League with early defeats against relegated Leyton Orient and last season's play-off finalists Wycombe Wanderers.