Although the Pilgrims currently lie sixth in the League Two table, nine places and seven points above Northampton, their away form has been a weakness in their season to date.
Nine league games have resulted in a haul of two wins, two draws and five defeats while they have managed only five goals on the road to date (albeit conceding only eight).
Town, meanwhile, have taken sixteen points from a possible twenty-seven at Sixfields to keep themselves in mid-table.
The two sides met in Northampton earlier this year, Plymouth winning 2-0 thanks to goals from Reuben Reid and Lewis Alessandra.