Danny Jackman, Giles Coke, Adebayo Akinfenwa, Colin Larkin and Andy Holt are all doubtful.
The Cobblers have been boosted though by the arrival of Mark Little from Wolves. The defender will go straight into the starting line up as a replacement for Gabor Gyepes.
Marcus Bignot is pushing for a return to the Millwall squad after recovering from a knee problem.
Midfielder Dave Brammer (knee), Adrian Forbes (tonsilitis) and Ryan Smith (knee), have all recovered and are pushing for a place in the squad.