League Two's bottom club were narrowly beaten at Portsmouth on Saturday in a game which saw midfielder Matthew Bates taken off with a dead leg.
Nicky Featherstone came on as substitute and impressed manager Ronnie Moore and may start against the Cobblers.
Reading loanee Aaron Tshibola played against Pompey with a tight groin but is also a doubt for Tuesday night.
Northampton welcome back Ryan Cresswell after a one-game ban and he will come back into the side for Zander Diamond who suffered a tight hamstring against Morecambe on Saturday.
Chris Wilder has confirmed he will otherwise keep the same starting XI.