There is sure to be a vibrant atmosphere at Home Park as leaders Argyle welcome the team one place and three points behind them in League Two, Northampton having a game in hand on their hosts.
While the Cobblers were playing out an exciting FA Cup draw with MK Dons, Plymouth had a free weekend to plot their plans for the visit of Chris Wilder's in-form side.
After a surprise home defeat by Cambridge in their first December outing, the Pilgrims have reeled off four successive victories, their last outing against Carlisle at the start of January being rewarded with a 2-0 win at Blackburn's Ewood Park with flood damage preventing the game being played in Cumbria.
And that was the same scoreline that Plymouth secured at Sixfields in the long-forgotten days of August, Chris Wilder admitting afterwards that his side had not deserved anything from the game.
That proved to be just a temporary blip in Town's fortunes and they will journey to Devon in high spirits.